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Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological pathways of cells. The term "proteomics" was coined to make an analogy with genomics, the study of the genes. The word "proteome" is a portmanteau of "protein" and "genome". The proteome of an organism is the set of proteins produced by it during its life, and its genome is its set of genes. Proteomics is often considered the next step in the study of biological systems, after genomics. It is much more complicated than genomics, mostly because while an organism's genome is rather constant, a proteome differs from cell to cell and constantly changes through its biochemical interactions with the genome and the environment. One organism has radically different protein expression in different parts of its body, different stages of its life cycle and different environmental conditions. Another major difficulty is the complexity of proteins relative to nucleic acids.

COURSE CURRICULUM

The course includes experiments both in wet lab and computational methodologies.

  • Introduction to Proteins, Form and content of Protein Structure and Data, Protein Chemistry and Intermolecular Forces
  • Protein Identification, Structure and Function Determination, Structure Comparison methods
  • Secondary structure Formation, Secondary Structure based Fold Classification
  • Automated fold classification methods.
  • Chemical properties of Protein Surfaces, Protein Engineering, Protein Biosynthesis.
  • Protein Transport, Protein Property conservation in evolution.
  • Molecular evolution from the Protein perspective, motifs, searching with motifs
  • Profiles, Predicting secondary structure from sequence, fold recognition from Sequence
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